Neglected Applications of Monolithic Structures: Advanced Thin Layer Chromatography-Mass Spectrometry Approaches

Applications of Hadamard transform to gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry.

Successful application of the Hadamard transform (HT) technique to gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) is described. Novel sample injection devices were developed to achieve multiple sample injections in both GC and LC instruments. Air pressure was controlled by an electromagnetic valve in GC, while a syringe pump and Tee connector we...

Thin-layer chromatography/desorption electrospray ionization mass spectrometry: investigation of goldenseal alkaloids.

Desorption electrospray ionization mass spectrometry was investigated as a means to qualitatively identify and to quantify analytes directly from developed normal-phase thin-layer chromatography plates. The atmospheric sampling capillary of a commercial ion trap mass spectrometer was extended to permit sampling and ionization of analytes in bands separated on intact TLC plates (up to 10 cmx10 c...

Trace analysis of acrylamide by high-performance thin-layer chromatography coupled to mass spectrometry

Thin-layer chromatography and electrospray mass spectrometry coupled using a surface sampling probe.

A combined surface sampling probe/electrospray emitter was used for the direct readout of thin-layer chromatography plates by electrospray mass spectrometry. The technique was demonstrated with reversed-phase C18 plates using a three-dye mixture composed of methylene blue, crystal violet, and rhodamine 6G for positive ion mode detection and a separate dye mixture containing fluorescein, naphtho...

Thin-layer chromatography combined with diode laser induced desorption/atmospheric pressure chemical ionization mass spectrometry

———————————————————————————————— ————————————————————————————————— 3 Abstract An analytical technique to combine TLC with MS was developed. The initial study was carried out on a graphite plate, which functions as a photon absorbing material. A continuous wave diode laser replaced traditional pulsed lasers as the desorption source, which was employed for this purpose for the first time. The the...